American Restaurants in Port St. Lucie, FL

American in Port St. Lucie at a glance

• American is the 12th largest food category in Port St. Lucie, after pizza and bakeries and donuts.
• Its 2.9% share compares with 3.8% across the 506 cities in this guide, close to the national pattern.
• Of the 16 listed below, 14 are independent and 2 belong to chains; 14 list a website.

American Restaurants in Port St. Lucie

• Applebee's
  Restaurant · American · Chain · 10501 South U.S. Highway 1
• Blu Ocean Grille Restaurant inside Encore at Tradition
  Restaurant · American · 8500 America Walks Blvd
• Cafe772 Cantina & Grill
  Restaurant · American · Latin American · 331 SE Port St Lucie Blvd
• Rick's Diner
  Restaurant · American · 466 SW Port St Lucie Blvd
• The Chicken Place Latin Rotisserie & Cocktail Bar
  Restaurant · American · Latin American · 10228 SW Meeting St
• Zest Kitchen & Bar
  Restaurant · American · 1347 St Lucie W Blvd
• Wings Bomb
  Restaurant · American · 10923 S US Highway 1
• Linda's Cafe
  Restaurant · American · 1308 St Lucie W Blvd
• Akra Kreole Restaurant
  Restaurant · American · 6518 NW Selvitz Rd
• Cody's Original Roadhouse
  Restaurant · American · 790 SW Saint Lucie West Blvd
• Palm City Grill
  Restaurant · American · 1347 NW Saint Lucie West Blvd
• Redfish Rick's Neighborhood Grill
  Restaurant · American · 3427 SW Darwin Blvd
• West End Grill
  Restaurant · American · 1680 St Lucie W Blvd
• Perkins at 9202 S Federal Highway Port St. Lucie, FL
  Restaurant · American · Chain · 9202 S Federal Highway
• Delicias De La Abuela
  Restaurant · American · Latin American
• Cafe772
  Restaurant · American · Latin American · 2360 SE Rivergate Pkwy

American elsewhere in Florida

Among the Florida cities in this guide, the most american listings are in Jacksonville (172), Miami (169), Tampa (130), Orlando (111), Fort Lauderdale (89) and Miami Beach (88).

Run a american spot in Port St. Lucie?

You share this list with 15 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.