American Restaurants in Winston-Salem, NC

American in Winston-Salem at a glance

• American is the 6th largest food category in Winston-Salem, after bars and coffee shops and cafes.
• Its 6.0% share compares with 3.8% across the 506 cities in this guide, so Winston-Salem leans toward american.
• Of the 60 listed below, 45 are independent and 15 belong to chains; 58 list a website.

American Restaurants in Winston-Salem

• Rooster's Wood-fired Kitchen Winston Salem
  Restaurant · American · Southern and soul food · Chain · 380 Knollwood St
• Mama Zoe's
  Restaurant · American · Southern and soul food · 2859 Reynolda Rd
• The Sherwood
  Restaurant · American · 3348 Robinhood Rd
• Sir Winston Wine Loft & Restaurant
  Restaurant · American · 104 W 4th St
• Applebee's
  Restaurant · American · Chain · 1990 Griffith Rd
• Betty on Burke
  Restaurant · American · 1016 Burke St Ste D
• Cagney's Kitchen
  Restaurant · American · Chain · 2201 Cloverdale Ave
• Cook Out
  Restaurant · American · Chain · 2897 Reynolda Rd
• Cracker Barrel
  Restaurant · American · Southern and soul food · Chain · 1750 Pecan Ln
• Dairi-O
  Restaurant · American · Chain · 1207 W Clemmonsville Rd
• Diamondback Grill
  Restaurant · American · 751 Avalon Rd N
• Los Primos Restaurant and Bar
  Restaurant · American · Latin American · 5083 University Pkwy
• Milner's American Southern Restaurant and Catering
  Restaurant · American · Southern and soul food · 630 S Stratford Rd
• Mozelle's
  Restaurant · American · Southern and soul food · 878 W 4th St
• Noble's Grille
  Restaurant · American · 380 Knollwood St
• Sage & Salt Bistro
  Restaurant · American · 300 S Liberty St
• Sweet Potatoes
  Restaurant · American · Southern and soul food · 607 N Trade St
• Meta's Restaurant
  Restaurant · American · Southern and soul food · 102 W 3rd St
• Showmars
  Restaurant · American · Southern and soul food · Chain · 227 Harvey St Ste 227
• Fords Food Hall
  Restaurant · American · 633 N Liberty St
• East Coast Wings + Grill
  Restaurant · American · Chain · 2894 Reynolda Rd
• Johnny B's Grillhouse
  Restaurant · American · 2504 Somerset Center Dr
• Applebee's
  Restaurant · American · Chain · 4690 N. Patterson Avenue
• Bleu Restaurant and Bar
  Restaurant · American · 3425 Frontis St
• River Birch Lodge
  Restaurant · American · 3324 Robinhood Rd
• The Old Fourth Street Filling Station
  Restaurant · American · 871 W 4th St
• Twisted Pine
  Restaurant · American · 527 N Liberty St
• Sabor Latin Street Grill - Winston Salem
  Restaurant · American · Latin American · Chain · 57 Miller St
• Murphy's 2010
  Restaurant · American · 207 W 3rd St
• Super Foods Tienda Latina - Carniceria - y Taqueria
  Restaurant · American · Latin American · 5952 University Pkwy
• 1703 Restaurant & Catering
  Restaurant · American · 1703 Robinhood Rd
• Cat's Corner Cafe
  Restaurant · American · 411 W 4th St
• Dirty Fries
  Restaurant · American · Chain · 2440 N Liberty St
• Grill-Ville
  Restaurant · American · 902 E Sprague St
• Ham's
  Restaurant · American · 367 Lower Mall Dr
• Mac & Nelli's
  Restaurant · American · 4926 Country Club Rd
• Mr. Waffle
  Restaurant · American · 649 Peters Creek Pkwy
• Phoenix Grille
  Restaurant · American · 115 S Main St
• Que Viva Latin Street Grill
  Restaurant · American · Latin American · 177 Jonestown Rd
• Stratford Station Grill
  Restaurant · American · 828 S Stratford Rd
• West-Town Eatery & Express
  Restaurant · American · 5584 Shattalon Dr
• Southern Family Restaurant
  Restaurant · American · Southern and soul food · 4689 Yadkinville Rd
• Ranch-O-Drive in
  Restaurant · American · 3020 Kernersville Rd
• BJ's
  Restaurant · American · Chain · 192 Hanes Mall Circle
• Pleasants Provisions
  Restaurant · American · 830 W 4th St
• Artisan Restaurant and Bar
  Restaurant · American · 310 A. West Fourth St.
• Bayberry Bistro
  Restaurant · American · Hawthorne St
• Deacon Tower Grille
  Restaurant · American · 475 Deacon Blvd
• Hickory Tavern
  Restaurant · American · 206 Harvey Street
• Hooters
  Restaurant · American · Chain · 120 Hanes Square Circle,
• Hwy. 55 Burgers Shakes & Fries
  Restaurant · American · 386 E Hanes Mill Rd
• IHOP
  Restaurant · American · Chain · 3000 University Parkway
• O'Charley's
  Restaurant · American · 300 E Hanes Mill Road
• Social Southern Kitchen & Cocktails
  Restaurant · American · Southern and soul food · 5232 Robinhood Village Dr
• TGI Fridays
  Restaurant · American · Chain · 348 Silas Creek Pkwy
• the Honey Pot
  Restaurant · American · Southern and soul food · 285 W. 4th St.
• The Piedmont Club
  Restaurant · American · 200 W 2nd Street 19th Floor
• Willow's Bistro
  Restaurant · American · 300 S Liberty St #125
• Zoe's Family Restaurant
  Restaurant · American · 3060 Trenwest Dr
• Southern Thyme Tavern
  Restaurant · American

American elsewhere in North Carolina

Among the North Carolina cities in this guide, the most american listings are in Charlotte (216), Raleigh (91), Greensboro (66), Durham (65), Asheville (65) and Wilmington (37).

Run a american spot in Winston-Salem?

You share this list with 59 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.