American Restaurants in Knoxville, TN

American in Knoxville at a glance

• American is the 6th largest food category in Knoxville, after bars and pizza.
• Its 5.2% share compares with 3.8% across the 506 cities in this guide, so Knoxville leans toward american.
• Of the 60 listed below, 45 are independent and 15 belong to chains; 60 list a website.

American Restaurants in Knoxville

Showing 60 of 74, listings with a website first.

• Lempira Mexican Restaurant & Latin Cuisine
  Restaurant · American · Latin American · 8078 Kingston Pike
• Gus's World Famous Fried Chicken
  Restaurant · American · Southern and soul food · Chain · 3101 Sutherland Ave
• Applebee's
  Restaurant · American · Chain · 261 North Peters Road
• The Marlowe
  Restaurant · American · 1123 N Central St
• Danielle's Dining and Drinks
  Restaurant · American · 9134 Executive Park Dr.
• Cracker Barrel Old Country Store
  Restaurant · American · Chain · 5001 Central Ave Pike
• Applebee's
  Restaurant · American · Chain · 2912 Knoxville Center Dr
• Bistro By The Tracks
  Restaurant · American · 215 Brookview Center Way
• Captain Jack's
  Restaurant · American · Southern and soul food · 2701 E Magnolia Ave
• Cazzy's Corner Grill
  Restaurant · American · 2099 Thunderhead Rd
• Corner16
  Restaurant · American · 9637 Kroger Park Dr
• Emma's Southern Kitchen
  Restaurant · American · Southern and soul food · 3701 Sutherland Ave NW
• Freakyz Wingz
  Restaurant · American · 2517 Martin Luther King Jr Ave
• J.C. Holdway
  Restaurant · American · Southern and soul food · 501 Union Ave
• Jackie's Dream
  Restaurant · American · Southern and soul food · 1008 E Woodland Ave
• Maple Street Biscuit Company
  Restaurant · American · Chain · 9314 Kingston Pike #112
• Myrtle's Chicken And Beer
  Restaurant · American · Southern and soul food · 13 Market Sq
• Not Watson's Kitchen and Bar
  Restaurant · American · 15 Market Square
• O'charley's Restaurant & Bar
  Restaurant · American · 3050 S Mall Rd NE
• Parkside Grill
  Restaurant · American · 338 N Peters Rd
• Ruby Tuesday
  Restaurant · American · Chain · 7406 Chapman Hwy
• Sonny's Original Southern Pub
  Restaurant · American · Southern and soul food · 2613 Adair Dr
• Southern Grit
  Restaurant · American · Southern and soul food · 126 S Central St
• Southern Kitchen
  Restaurant · American · Southern and soul food · 1525 White Ave
• Sullivan's Fine Food
  Restaurant · American · Southern and soul food · 7545 S Northshore Dr
• Tupelo Honey
  Restaurant · American · Southern and soul food · Chain · 1 Market Square
• Vida
  Restaurant · American · Latin American · 531 S Gay St SW
• Applebee's Grill + Bar
  Restaurant · American · Chain · 5316 Central Ave Pike
• Order Up Cafe
  Restaurant · American · 800 S Gay St
• Oliver Royale
  Restaurant · American · Southern and soul food · Chain · 5 Market Square
• Inskip Grill
  Restaurant · American · 101 inskip Drive
• The Cheesecake Factory
  Restaurant · American · Chain · 201 Morrell Rd
• Litton's
  Restaurant · American · 2803 Essary Dr
• Redbud Kitchen
  Restaurant · American · 906 Sevier Ave
• Aubrey's Powell
  Restaurant · American · Southern and soul food · Chain · 214 E Emory Rd
• Shoney's
  Restaurant · American · Southern and soul food · Chain · 4032 N Broadway
• Champion Smokers & Grills
  Restaurant · American · 2008 Hoitt Ave
• O'charley's Restaurant & Bar
  Restaurant · American · 8077 Kingston Pike
• The Chef's Table
  Restaurant · American · 9111A Executive Park Dr NW
• Mahogany's Restaurant
  Restaurant · American · 401 W Summit Hill Dr SW
• Calhoun's On The River
  Restaurant · American · Chain · 400 Neyland Dr
• Babalu - Knoxville
  Restaurant · American · Latin American · 412 S Gay St
• Earl’s Knoxville
  Restaurant · American · Southern and soul food · 610 Waterfront Dr
• Brown Bag Downtown
  Restaurant · American · Chain · 800 S Gay St
• Cumberland Grille
  Restaurant · American · 1807 Cumberland Ave
• Great American Steakhouse & Buffet
  Restaurant · American · 900 Merchant Dr
• Gus's World Famous Fried Chicken
  Restaurant · American · Southern and soul food · Chain · 126 Lovell Rd
• Knox Mason
  Restaurant · American · Southern and soul food · 131 S Gay St
• Lema's World's Famous Chittlins
  Restaurant · American · 3931 Holston Dr
• O'charley's Restaurant & Bar
  Restaurant · American · 117 Cedar Ln
• Old College Inn Restaurant
  Restaurant · American · 113 N Peters Rd
• Peerless Restaurant
  Restaurant · American · 320 N Peters Rd
• Philly Connection
  Restaurant · American · 9724 Kingston Pike
• Puleo's Grille
  Restaurant · American · Southern and soul food · 260 N Peters Rd
• Puleo's Grille
  Restaurant · American · 5503 Kingston Pike
• Puleo's Grille
  Restaurant · American · Southern and soul food · 110 Cedar Ln
• Puleo's Grille
  Restaurant · American · Southern and soul food · 7224 Region Ln
• Rouxbarb
  Restaurant · American · 130 S Northshore Dr
• Seasons
  Restaurant · American · 5018 Kingston Pike
• Shoney's
  Restaurant · American · 4410 Western Ave

American elsewhere in Tennessee

Among the Tennessee cities in this guide, the most american listings are in Nashville (244), Memphis (159), Chattanooga (66), Franklin (26), Murfreesboro (25) and Clarksville (20).

Run a american spot in Knoxville?

You share this list with 73 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.