American in Irvine at a glance
- American is the 11th largest food category in Irvine, after coffee shops and cafes and japanese.
- Its 3.2% share compares with 3.8% across the 506 cities in this guide, close to the national pattern.
- Of the 37 listed below, 21 are independent and 16 belong to chains; 36 list a website.
American Restaurants in Irvine
- Restaurant · American · Chain · 18169 Von Karman Ave
- Restaurant · American · Chain · 17927 MacArthur Blvd
- Restaurant · American · Chain · 4143 Campus Dr
- Restaurant · American · 19100 Von Karman Ave
- Restaurant · American · 800 Spectrum Center Dr
- Restaurant · American · Latin American · 13126 Jamboree Rd
- Restaurant · American · Chain · 17380 Red Hill Ave
- Restaurant · American · 5301 California Ave #140
- Restaurant · American · Chain · 3966 Barranca Pkwy
- Restaurant · American · 2000 Main St Ste 200
- Restaurant · American · Chain · 5633 Alton Pkwy #200
- Restaurant · American · Chain · 13380 Jamboree Rd
- Restaurant · American · Chain · 7700 Irvine Center Dr Ste 300
- Restaurant · American · Chain · 18555 Jamboree Rd
- Restaurant · American · 705 Spectrum Center Dr
- Restaurant · American · Chain · 4511 Campus Dr
- Restaurant · American · 90 Pacifica
- Restaurant · American · 18000 Von Karman Ave
- Restaurant · American · 2967 Michelson Dr
- Restaurant · American · 7905 Irvine Center Dr
- Restaurant · American · Chain · 600 Spectrum Center Dr
- Restaurant · American · Chain · 2991 Michelson Dr
- Restaurant · American · 1 Park Plz
- Restaurant · American · Chain · 3935 Alton Pkwy
- Restaurant · American · 13274 Jamboree Rd
- Restaurant · American · Chain · 15791 Rockfield Blvd
- Restaurant · American · 2626 Dupont Dr Ste 70
- Restaurant · American · 18007 Von Karman Ave
- Restaurant · American · 13390 Jamboree Rd
- Restaurant · American · 2600 Michelson Dr
- Restaurant · American · 19530 Jamboree Rd
- Restaurant · American · 18700 MacArthur Blvd
- Restaurant · American · Chain · 57 Fortuna E
- Restaurant · American · Latin American · 16221 Construction Cir W
- Restaurant · American · 407 Spectrum Center Drive
- Restaurant · American · Chain · 17701 Mitchell N Ste 100
- FLOE RestaurantRestaurant · American · 18000 Von Karman Ave
American elsewhere in California
Among the California cities in this guide, the most american listings are in Los Angeles (547), San Francisco (301), San Diego (228), Sacramento (107), Oakland (97) and San Jose (77).
Run a american spot in Irvine?
You share this list with 36 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.
Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.