American Restaurants in Gainesville, FL

American in Gainesville at a glance

• American is the 6th largest food category in Gainesville, after coffee shops and cafes and bars.
• Its 5.2% share compares with 3.8% across the 506 cities in this guide, so Gainesville leans toward american.
• Of the 44 listed below, 36 are independent and 8 belong to chains; 42 list a website.

American Restaurants in Gainesville

• Perkins Restaurant & Bakery
  Restaurant · American · Chain · 6825 W Newberry Rd
• Los Pollos
  Restaurant · American · Latin American · 3120 SW Archer Rd
• Mildred's Big City Food
  Restaurant · American · 3445 W University Ave
• New Deal Cafe
  Restaurant · American · 3443 W University Ave
• Newk's Eatery
  Restaurant · American · Chain · 4041 Plaza Blvd
• Applebee's
  Restaurant · American · Chain · 1005 NW 13th St
• Blue Gill Quality Food
  Restaurant · American · Southern and soul food · 2917 SW 35th Dr Ste 20
• Frenchmen Street Food | Cajun
  Restaurant · American · Southern and soul food · 439 S Main St
• Sandwich Inn
  Restaurant · American · 110 NE 16th Ave
• Tela Latin Grill
  Restaurant · American · Latin American · 1702 W University Ave
• Terrace Market Cafe
  Restaurant · American · 1515 SW Archer Rd
• Tinker Latin Restaurant & Food Truck
  Restaurant · American · Latin American · 502 S Main St
• Underground Kitchen
  Restaurant · American · Southern and soul food · 722 NW 5th Ave
• Arredondo Cafe
  Restaurant · American · 114 PO
• Gators Dockside Gainesville
  Restaurant · American · 3842 Newberry Rd Ste 1a
• Original American Kitchen
  Restaurant · American · Southern and soul food · 15 SE 1st Ave
• Cheddar's
  Restaurant · American · Chain · 3989 Plaza Blvd
• Southern Stop
  Restaurant · American · Southern and soul food · 6419 W Newberry Rd
• Dick Mondell's
  Restaurant · American · 412 SW 4th Ave
• Gator's Dockside
  Restaurant · American · 3842 Newberry Rd
• 101 Downtown
  Restaurant · American · 201 SE 2nd Ave #101
• California Chicken Grill
  Restaurant · American · 2124 SW 34th St
• Corner
  Restaurant · American · Latin American · 1220 W University Ave
• Gator Dawgs
  Restaurant · American · 1023 W University Ave
• Grandy's
  Restaurant · American · Chain · 3401 W University Ave
• Huddle House
  Restaurant · American · Chain · 1520 SW 13th St
• Phil-Nicks
  Restaurant · American · Southern and soul food · 37 N Main St
• Piper Gi's
  Restaurant · American · 204 SW 2nd Ave
• Ruby's "A Great Place To Eat"
  Restaurant · American · Southern and soul food · 308 NW 5th Ave
• Stonewood Grill & Tavern
  Restaurant · American · 3812 W Newberry Rd
• TGI Friday's
  Restaurant · American · Chain · 3075 Clark Butler Blvd
• The Jones B-Side
  Restaurant · American · 203 SW 2nd Ave
• The Jones Eastside
  Restaurant · American · 401 NE 23rd Ave
• The Leaning Pig
  Restaurant · American · 11 SE 1st Ave
• The Warehouse Restaurant and Lounge
  Restaurant · American · 502 S Main St
• Vellos Historic Brickstreet Grill
  Restaurant · American · 115 SE 1st Ave
• WZ Eats
  Restaurant · American · 923 W University Ave
• Xpress Grille
  Restaurant · American · 490 NE 23rd Ave
• Perkins at 6825 W Newberry Road Gainesville, FL
  Restaurant · American · Chain · 6825 W Newberry Road
• Lisa's Corner Café
  Restaurant · American · 125 NW 23rd Ave Ste 9-10
• Red Onion Neighborhood Grill
  Restaurant · American · 3885 NW 24th Blvd #A
• The Sandwich Depot
  Restaurant · American · 6500 W Newberry Rd
• Emiliano's Cafe
  Restaurant · American · Latin American · 7 SE 1st Ave
• 43rd Street Deli & Breakfast House
  Restaurant · American · 1505 NW 13th St

American elsewhere in Florida

Among the Florida cities in this guide, the most american listings are in Jacksonville (172), Miami (169), Tampa (130), Orlando (111), Fort Lauderdale (89) and Miami Beach (88).

Run a american spot in Gainesville?

You share this list with 43 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.