Seafood Restaurants in Durham, NC

Seafood in Durham at a glance

• Seafood is the 14th largest food category in Durham, after coffee shops and cafes and bars.
• Its 2.0% share compares with 1.9% across the 506 cities in this guide, close to the national pattern.
• Of the 27 listed below, 17 are independent and 10 belong to chains; 26 list a website.

Seafood Restaurants in Durham

• ZenFish
  Restaurant · Seafood · Chain · 810 9th St
• Bonefish Grill
  Restaurant · Seafood · Chain · 7820 NC-751
• Mayflower XVI Seafood Restaurant
  Restaurant · Seafood · 3742 Durham-Chapel Hill Blvd
• Capital Seafood Market
  Restaurant · Seafood · 1304 University Dr
• Crab Sea
  Restaurant · Seafood · 4831 NC-55
• Mr. Shark Fish and Chicken
  Restaurant · Seafood · 3825 S Roxboro St
• Nantucket Grill
  Restaurant · Seafood · Chain · 5925 Farrington Rd
• Red Crab Juicy Seafood
  Restaurant · Seafood · Chain · 4600 Durham-Chapel Hill Blvd Ste.29-30
• Saltbox Seafood Joint
  Restaurant · Seafood · 2637 Durham-Chapel Hill Blvd
• Shuckin' Shack Oyster Bar
  Restaurant · Seafood · Chain · 2200 W Main St
• Skrimp Shack
  Restaurant · Seafood · Chain · 3600 N Duke St #28b
• Pokeworks
  Restaurant · Seafood · Chain · 122 W Main St
• Nerra
  Restaurant · Seafood · 506 Ramseur St Ste 2
• ZenFish Poke Bar
  Restaurant · Seafood · Chain · 105 W North Carolina 54 #261
• Hook & Reel Cajun Seafood & Bar
  Restaurant · Seafood · Chain · 2608 Erwin Rd Ste 104
• Saint James Seafood
  Restaurant · Seafood · 806 W Main St
• Big T's Fry Fish
  Restaurant · Seafood · 2945 S Miami Blvd
• Locals Seafood Restaurant and Market
  Restaurant · Seafood · Chain · 530 Foster St
• R & B Seafood Box
  Restaurant · Seafood · 518 E Trinity Ave
• SALTBOX SEAFOOD JOINT
  Restaurant · Seafood · 608 N Mangum St
• Sho Nuff Seafood
  Restaurant · Seafood · 1104 Broad St
• Sho Nuff Seafood
  Restaurant · Seafood · 1007 W Chapel Hill St
• The House Fish & Crab
  Restaurant · Seafood · 1903 NC-55
• The Saucy Crab
  Restaurant · Seafood · 4020 Durham Chapel Hill Blvd
• Blu Seafood and Bar
  Restaurant · Seafood · 2002 Hillsborough Rd
• Sho Nuff Seafood
  Restaurant · Seafood · 1104 Broad St
• Piney Point Grill and Seafood Bar
  Restaurant · Seafood · 2515 Meridian Pkwy

Seafood elsewhere in North Carolina

Among the North Carolina cities in this guide, the most seafood listings are in Charlotte (64), Wilmington (35), Raleigh (34), Greensboro (26), Fayetteville (24) and Winston-Salem (13).

Run a seafood spot in Durham?

You share this list with 26 other seafood listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.