American Restaurants in Des Moines, IA

American in Des Moines at a glance

• American is the 6th largest food category in Des Moines, after bars and mexican.
• Its 4.4% share compares with 3.8% across the 506 cities in this guide, close to the national pattern.
• Of the 43 listed below, 34 are independent and 9 belong to chains; 40 list a website.

American Restaurants in Des Moines

• HoQ Restaurant
  Restaurant · American · 303 E 5th St
• Hy-Vee Market Grille
  Restaurant · American · Chain · 3221 SE 14th St
• Perkins Restaurant and Bakery
  Restaurant · American · Chain · 4601 Merle Hay Rd
• Tupelo Honey
  Restaurant · American · Southern and soul food · Chain · 665 Grand Ave Ste 100
• Fresko
  Restaurant · American · 909 Locust St Ste. 103
• Alba Restaurant
  Restaurant · American · 524 E 6th St
• Chuck's Restaurant
  Restaurant · American · 3610 6th Ave
• Either Or
  Restaurant · American · 6222 Grand Ave
• La Centroamericana
  Restaurant · American · Latin American · 1130 E 9th St
• Malo
  Restaurant · American · Latin American · 900 Mulberry St
• Mullets
  Restaurant · American · 1300 SE 1st St
• Proudfoot & Bird
  Restaurant · American · 1000 Walnut St
• Skip's
  Restaurant · American · 4000 Fleur Dr
• Table 128
  Restaurant · American · 220 SW 9th St Ste 120
• Vibes Kitchen & Bar
  Restaurant · American · 1303 Walnut St
• Cub Club
  Restaurant · American · 1 Line Dr
• Applebee's
  Restaurant · American · Chain · 3900 Merle Hay Rd
• Applebee's
  Restaurant · American · Chain · 6301 SE 14th St
• La Cuscatleca Pupuseria & Restaurant
  Restaurant · American · Latin American · 1832 Hubbell Ave
• Rock River Grill & Tavern
  Restaurant · American · 700 Grand Ave
• Chef's Kitchen
  Restaurant · American · 1903 Beaver Ave
• Cozy Cafe
  Restaurant · American · 6401 SE 14th St
• Cozy Café
  Restaurant · American · 5405 Douglas Ave
• Eastside Grill
  Restaurant · American · 2905 Hubbell Ave
• Genevieve's Grill
  Restaurant · American · 1050 6th Ave
• J. Benjamin's
  Restaurant · American · 5800 Franklin Ave
• Patton's Restaurant
  Restaurant · American · Southern and soul food · 1552 E Grand Ave
• Proof Restaurant
  Restaurant · American · 1301 Locust St Ste C
• Tally's Restaurant
  Restaurant · American · 2712 Beaver Ave
• The Home Plate Diner
  Restaurant · American · 3900 E 14th St
• Village Inn Restaurants
  Restaurant · American · Chain · 1140 E Army Post Rd
• Diamond Jack's
  Restaurant · American · 3000 E Grand Ave
• Perkins at 2000 SW McKinley Ave. Des Moines, IA
  Restaurant · American · Chain · 2000 SW McKinley Ave.
• Perkins at 2425 E Euclid Ave. Des Moines, IA
  Restaurant · American · Chain · 2425 E Euclid Ave.
• Perkins at 4601 Merle Hay Rd. Des Moines, IA
  Restaurant · American · Chain · 4601 Merle Hay Rd.
• Hole In The Wall
  Restaurant · American · 1501 Grand Ave
• Legends American Grill
  Restaurant · American · 216 Court Ave
• Local Yocals Farmhouse
  Restaurant · American · 700 Locust St
• The Home Plate Diner
  Restaurant · American · 304 E 30th Street
• United Methodist Church
  Restaurant · American · Sheep Barn
• Usuluteco Salvadoran Restaurant
  Restaurant · American · Latin American · 1511 S Union St
• Hy-Vee Market Grille Express
  Restaurant · American · 420 Court Ave
• The Real Chicago Style Food Truck
  Restaurant · American · 1810 2nd Ave

American elsewhere in Iowa

Among the Iowa cities in this guide, the most american listings are in Cedar Rapids (44), Davenport (19), Sioux City (14), Ankeny (12) and Iowa City (8).

Run a american spot in Des Moines?

You share this list with 42 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.

Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.