American in Columbia at a glance
- American is the 5th largest food category in Columbia, after bars and coffee shops and cafes.
- Its 5.0% share compares with 3.8% across the 506 cities in this guide, so Columbia leans toward american.
- Of the 46 listed below, 36 are independent and 10 belong to chains; 41 list a website.
American Restaurants in Columbia
- Restaurant · American · Chain · 5185 Fernandina Road
- Restaurant · American · Chain · 4505 Devine Street
- Restaurant · American · 1215 Assembly St
- Restaurant · American · Southern and soul food · Chain · 1140 Kinley Rd. I-26 & Lake Murray Rd.
- Restaurant · American · Southern and soul food · 1260 Bower Pkwy
- Restaurant · American · Southern and soul food · Chain · 818 Elmwood Ave
- Restaurant · American · 1320 Main St
- Restaurant · American · Latin American · 2180 Boyce St Ste A
- Restaurant · American · Southern and soul food · 751 Saluda Ave
- Restaurant · American · 1221 Main St
- Restaurant · American · 1614a Main St
- Restaurant · American · Chain · 7490 Garners Ferry Rd
- Restaurant · American · Chain · 2865 Devine St
- Restaurant · American · Southern and soul food · Chain · 2138 Pickens St
- Restaurant · American · Chain · 401 Main St
- Restaurant · American · 3217 Devine St
- Restaurant · American · Southern and soul food · 1200 Hampton St
- Restaurant · American · 1809 Laurel St
- Restaurant · American · Southern and soul food · 2001 Greene St A
- Restaurant · American · 1621 Main St
- Restaurant · American · Southern and soul food · 5590 Forest Dr
- Restaurant · American · 100 Columbiana Cir
- Restaurant · American · Southern and soul food · 1410 Colonial Life Blvd W Ste 150
- Restaurant · American · Southern and soul food · 100 Pontiac Buiness Center Drive
- Restaurant · American · 421 Bush River Rd Unit 270
- Restaurant · American · 1230 Bower Pkwy
- Restaurant · American · 1212 Hampton St
- Restaurant · American · 1220 Bower Pkwy
- Restaurant · American · 100 Columbiana Cir
- Restaurant · American · 1840 Hampton St
- Restaurant · American · 700 Harden St
- Restaurant · American · Chain · 111 Sparkleberry Crossing Rd #11
- Restaurant · American · 120 Sparkleberry Crossing Rd Ste 4
- Restaurant · American · 421 Bush River Rd Unit 184
- Restaurant · American · 930 Gervais St
- Restaurant · American · 566 Spears Creek Church Rd
- Restaurant · American · 1410 Colonial Life Blvd W
- Restaurant · American · 700 Lincoln St Ste 200
- Restaurant · American · 2030 Devine St
- Restaurant · American · Southern and soul food · 650 Lincoln St
- Restaurant · American · Chain
- Angelo's ZestoRestaurant · American · 4001 N Main St
- Mary's ArepasRestaurant · American · Latin American · 1500 Main St
- Blue MarlinRestaurant · American · 250 E Exchange Blvd
- Champagne RestaurantRestaurant · American · 902 Gervais St c
- M FreshRestaurant · American · 1237 Washington St
American elsewhere in South Carolina
Among the South Carolina cities in this guide, the most american listings are in Charleston (84), North Charleston (34), Rock Hill (26) and Mount Pleasant (25).
Run a american spot in Columbia?
You share this list with 45 other american listings. The ones guests reorder from are the ones that are easy to order from directly. Servestack gives you your own ordering site with zero commission, and Studio designs the menu, flyers and posts to go with it. Run your numbers with the commission savings calculator.
Place data from the Overture Maps Foundation (overturemaps.org), which includes data from Meta, Microsoft and Foursquare, used under the CDLA Permissive 2.0 and Apache 2.0 licenses. Restaurants open, close and move; check with the restaurant before you go. Data refreshed 2026-10-11.